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5-Fluoro-2'-deoxycytidine
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
5-Fluoro-2'-deoxycytidine图片
CAS NO:10356-76-0
包装:5mg
市场价:450元

产品介绍
5-Fluoro-2'-deoxycytidine，一种氟嘧啶核苷类似物，是DNA甲基转移酶(DNMT)抑制剂。5-Fluoro-2'-deoxycytidine是有效的胸苷酸合酶抑制剂5-fluoro-2′-dUMP的肿瘤选择性前药。
Cas No.10356-76-0
别名5-氟脱氧胞苷
Canonical SMILESOC[C@@H]1[C@@H](O)C[C@@H](O1)N2C(N=C(N)C(F)=C2)=O
分子式C9H12FN3O4
分子量245.21
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

5-Fluoro-2'-deoxycytidine, a fluoropyrimidine nucleoside analogue, is a DNA methyltransferase (DNMT) inhibitor. 5-Fluoro-2'-deoxycytidine is a tumor-selective prodrug of the potent thymidylate synthase inhibitor 5-fluoro-2′-dUMP[1][2].

[1]. Beumer JH, et, al. Pharmacokinetics, metabolism, and oral bioavailability of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine in mice. Clin Cancer Res. 2006 Dec 15;12(24):7483-91. [2]. Osterman DG, et, al. 5-Fluorocytosine in DNA is a mechanism-based inhibitor of HhaI methylase. Biochemistry. 1988 Jul 12;27(14):5204-10.