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Fluindione
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Fluindione图片
CAS NO:957-56-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
A vitamin K antagonist
Cas No.957-56-2
别名氟茚二酮
Canonical SMILESO=C1C2=C(C(C1C3=CC=C(C=C3)F)=O)C=CC=C2
分子式C15H9FO2
分子量240.2
溶解度DMF: insol,DMSO: 1 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): insol
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fluindione is a vitamin K antagonist.1It inhibits vitamin K epoxide reductase (VKOR; IC50= 6.6 nM), including VKOR containing certain substitution mutations. Fluindione inhibits platelet and fibrin deposition, as well as prevents β-thromboglobulin release and thrombin-antithrombin complex formation, in anex vivomodel of tissue factor-induced thrombus formation using isolated human whole blood.2Fluindione has previously been used in the treatment of emboligenic heart disease, deep vein thrombosis, pulmonary embolism, and in the prevention of thromboembolic complications in patients with heart disease.

1.Chen, X., Jin, D.-Y., Stafford, D.W., et al.Evaluation of oral anticoagulants with vitamin K epoxide reductase in its native milieuBlood132(18)1974-1984(2018) 2.Bossavy, J.P., Sakariassen, K.S., Thalamas, C., et al.Antithrombotic efficacy of the vitamin K antagonist fluindione in a human ex vivo model of arterial thrombosis: Effect of anticoagulation level and combination therapy with aspirinArterioscler. Thromb. Vasc. Biol.19(9)2269-2275(1999)