CAS NO: | 59060-36-5 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
Cas No. | 59060-36-5 |
别名 | 氘代3-羟基-3-甲基(D3) |
Canonical SMILES | OC(CC(C([2H])([2H])[2H])(O)CC(O)=O)=O |
分子式 | C6H7D3O5 |
分子量 | 165.2 |
溶解度 | DMF: 30mg/mL,DMSO: 30mg/mL,Ethanol: 30mg/mL,PBS (pH 7.2): 10mg/mL |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | Meglutol-d3is intended for use as an internal standard for the quantification of meglutol by GC- or LC-MS. Meglutol is an HMG-CoA reductase inhibitor (IC50= 4 nM) and antimetabolite of mevalonic acid.1Dietary administration of meglutol (10, 20, and 30 mg/kg per day) reduces serum total cholesterol levels in normal rats, as well as reduces them in high-cholesterol fed and hypercholesterolemic rats when administered in the drinking water at a dose of 50 mg/kg per day.2It also reduces serum levels of cholesterol, triglycerides, phospholipids, and free fatty acids, as well as the severity of aortic atherosclerotic lesions, in a rabbit model of atherosclerosis induced by a high-cholesterol diet when administered at a dose of 25 mg/animal per day.3Intracerebroventricular administration of meglutol (0.5 µmol/g) induces lipid peroxidation and decreases the activity of glutathione peroxidase in the cerebral cortex of one-day old rat pups.4Meglutol accumulates in the tissues and fluids of patients with HMG-CoA lyase deficiency, a disorder characterized by metabolic acidosis, hypoglycemia, and lethargy.4 1.Medina-Franco, J.L., LÓpez-Vallejo, F., RodrÍguez-Morales, S., et al.Molecular docking of the highly hypolipidemic agent α-asarone with the catalytic portion of HMG-CoA reductaseBioorg. Med. Chem. Lett.15(4)989-994(2005) 2.Beg, Z.H., and Siddiqi, M.Hypocholesterolemic effect of 3-hydroxy-3-methylglutaric acidExperientia23(5)380(1967) 3.Lupien, P.J., Tremblay, M., and Beg, Z.H.3-Hydroxy-3-methylglutaric acid: Protective action in experimental atherosclerosis in rabbitsAtherosclerosis18(3)407-416(1973) 4.da Rosa, M.S., da Rosa-Junior, N.T., Parmeggiani, B., et al.3-Hydroxy-3-methylglutaric acid impairs redox and energy homeostasis, mitochondrial dynamics, and endoplasmic reticulum-mitochondria crosstalk in rat brainNeurotox. Res.37(2)314-325(2020) |