CK2/ERK8-IN-1

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CK2/ERK8-IN-1

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CAS NO:

1085822-09-8

包装与价格：

包装	价格(元)
10mg	电议
50mg	电议
100mg	电议

产品介绍

CK2/ERK8-IN-1 是一种酪蛋白激酶 2 (CK2) (Ki 为 0.25 µM) 和 ERK8 的双重抑制剂，IC50 均为 0.50 μM。CK2/ERK8-IN-1 还与 PIM1，HIPK2 和 DYRK1A 结合，Ki 值分别为 8.65 µM，15.25 µM 和 11.9 µM。CK2/ERK8-IN-1 具有促凋亡 (pro-apoptotic) 作用。

Cas No.	1085822-09-8
Canonical SMILES	O=C(O)CN1C2=C(Br)C(Br)=C(Br)C(Br)=C2N=C1N(C)C
分子式	C₁₁H₉Br₄N₃O₂
分子量	534.82
溶解度	DMSO: 25 mM
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	CK2/ERK8-IN-1 is a dual casein kinase 2 (CK2) (Ki of 0.25 µM) and ERK8 inhibitor with IC50s of 0.50 μM. CK2/ERK8-IN-1 also binds to PIM1, HIPK2 (homeodomain-interacting protein kinase 2), and DYRK1A with Kis of 8.65 µM, 15.25 µM, and 11.9 µM, respectively. CK2/ERK8-IN-1 has pro-apoptotic efficacy[1]. [1]. Pagano MA, et al. The selectivity of inhibitors of protein kinase CK2: an update. Biochem J. 2008 Nov 1;415(3):353-65.