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Guanylyl Imidodiphosphate(lithium salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Guanylyl Imidodiphosphate(lithium salt)图片
CAS NO:64564-03-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Guanylyl imidodiphosphate (Gpp(NH)p) 锂是一种不可水解的 GTP 类似物,可增加腺苷酸环化酶活性。
Cas No.64564-03-0
别名Gpp(NH)p lithium
化学名5’-guanylic acid, monoanhydride with imidodiphosphoric acid, tetralithium salt
Canonical SMILESO[C@H]1[C@H](N2C=NC3=C2N=C(N)NC3=O)O[C@H](COP(OP(NP([O-])([O-])=O)([O-])=O)([O-])=O)[C@H]1O.[Li+].[Li+].[Li+].[Li+]
分子式C10H13N6O13P3o 4Li
分子量545.9
溶解度10mg/mL in PBS, pH7.2
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述
Guanylyl imidodiphosphate is a nonhydrolyzable analog of GTP that can bind to and irreversibly activate G proteins in the presence of Mg2+.[1] This nucleotide is a potent stimulator of adenylate cyclase.[2] Guanylyl imidodiphosphate is used in studies of protein synthesis since the process of GTP binding, hydrolysis, and release is essential for the initiation of protein translocation across the endoplasmic reticulum.[3]

Reference:
[1]. Terry, B.J., and Purich, D.L. Assembly and disassembly properties of microtubules formed in the presence of GTP, 5'-guanylyl imidodiphosphate, and 5'-guanylyl methylenediphosphate. The Journal of Biological Chemisty 255(21), 10532-10536 (1980).
[2]. Lefkowitz, R.J., and Caron, M.G. Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase. The Journal of Biological Chemisty 250(12), 4418-4422 (1975).
[3]. Rapoport, T.A. Transport of proteins across the endoplasmic reticulum membrane. Science 258(5084), 931-936 (1992).