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(±)2-(14,15-Epoxyeicosatrienoyl)Glycerol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(±)2-(14,15-Epoxyeicosatrienoyl)Glycerol图片
CAS NO:848667-56-1
包装与价格:
包装价格(元)
25μg电议
50μg电议
100μg电议

产品介绍
Cas No.848667-56-1
Canonical SMILESO=C(OC(CO)CO)CCC/C=C\C/C=C\C/C=C\C[C@H](O1)[C@H]1CCCCC
分子式C23H38O5
分子量394.5
溶解度DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 0.15 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. 2-AG is hydrolyzed by the enzyme monoacylglycerol lipase, terminating its biological activity, and metabolism by cyclooxygenase-2 and lipoxygenases has been documented. The related endocannabinoid, 2-arachidonoyl ethanolamide (AEA), can be metabolized by cytochrome P450 (CYP450) enzymes in human liver and kidney to a number of epoxy-ethanolamide derivatives. (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol ((±)2-14,15-EG) is a novel CYP450 metabolite of 2-AG in the kidney. (±)2-14,15-EG is a potent mitogen for renal epithelial cells, increasing DNA synthesis in LLCPKcl4 cells at concentrations as low as 100 nM and doubling cell proliferation rates at 1 µM. In these cells, (±)2-14,15-EG activates the metalloprotease ADAM17, which cleaves proTGF-α and releases TGF-α as a ligand that initiates the EGFR-ERK signalling pathway.