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Metadoxine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Metadoxine图片
CAS NO:74536-44-0
包装与价格:
包装价格(元)
10mM (in 1mL Water)电议
50mg电议

产品介绍
Metadoxine可通过阻断蛋白激酶A-cAMP反应原件结合蛋白(PKA-CREB)通路来阻断脂肪细胞的分化。
Cas No.74536-44-0
别名美他多辛
Canonical SMILESO=C(O)[C@H](CC1)NC1=O.OCC2=C(CO)C(O)=C(C)N=C2
分子式C13H18N2O6
分子量298.29
溶解度Water : ≥ 155 mg/mL (519.63 mM)
储存条件Store at -20°C, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Metadoxine blocks adipocyte differentiation in association with inhibition of the protein kinase A-cAMP response element binding protein (PKA-CREB) pathway.

Simultaneous Metadoxine treatment notably inhibits adipogenic differentiation in a dose-dependent manner. Metadoxine treatment from day 4 through day 8 is required for inhibition of MDI-induced preadipocyte differentiation[1]. Metadoxine prevents glutathione depletion and the increase in lipid peroxidation damage caused by ethanol and acetaldehyde in HepG2 cells. In hepatic stellate cells, Metadoxine prevents the increase in collagen and attenuated TNF-α secretion caused by acetaldehyde. Thus, Metadoxine could be useful in preventing the damage produced in early stages of alcoholic liver disease as it prevents the redox imbalance of the hepatocytes and prevents TNF-α induction, one of the earliest events in hepatic damage[2].

[1]. Yang YM, et al. Metadoxine, an ion-pair of pyridoxine and L-2-pyrrolidone-5-carboxylate, blocks adipocyte differentiation in association with inhibition of the PKA-CREB pathway. Arch Biochem Biophys. 2009 Aug 15;488(2):91-9.