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Belvarafenib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Belvarafenib图片
CAS NO:1446113-23-0
包装与价格:
包装价格(元)
250mg电议
500mg电议

产品介绍
Belvarafenib是一种有效的,广泛的迅速加速纤维肉瘤激酶(RAF)的抑制剂,其对B-RAF,B-RAFv600E和C-RAF的IC50值分别为56nM,7nM和5nM。
Cas No.1446113-23-0
别名HM95573; GDC-5573; RG6185
Canonical SMILESO=C(C(C1=NC=N2)=CSC1=C2N)NC(C3=C4C(NC(C=CC=C5Cl)=C5F)=NC=C3)=C(C=C4)C
分子式C23H16ClFN6OS
分子量478.93
溶解度DMSO: 12.5 mg/mL (26.10 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Belvarafenib is a potent and pan RAF (Rapidly Accelerated Fibrosarcoma) inhibitor, with IC50s of 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively.

Belvarafenib (Example 116) is a potent and pan RAF inhibitor with antineoplastic activity. The IC50 values of Belvarafenib are 56 nM, 7 nM and 5 nM for B-RAF, B-RAFv600E and C-RAF respectively. It also shows high inhibitory activity for FMS, DDR1 and DDR2 kinases, with IC50s of 10 nM, 23 nM and 44 nM, respectively[1].

[1]. WO 2013/100632 A1.