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RORγt inverse agonist 13
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
RORγt inverse agonist 13图片
CAS NO:2170477-75-3
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
RORγt inverse agonist 13 (Compound 3i) 是有效的、具有口服活性的、选择性的 RORγt 反向激动剂，其 IC50 值为 63.8 nM。
Cas No.2170477-75-3
分子式C23H17Cl2F3N2O4
分子量513.29
溶解度DMSO : 100 mg/mL (194.82 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM[1].

RORγt inverse agonist 13 (Compound 3i) exhibits activity with an inhibition of 76% at 0.3 µM in Th17 cell differentiation assay[1].

RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, Orally, twice daily) demonstrats excellent in vivo PK profile in mice and good in vivo efficacy in an IMQ-induced psoriasis mice model[1].

[1]. Nannan Sun, et al. Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists. Eur J Med Chem. 2020 Jul 5;202:112536.