CAS NO: | 2139287-33-3 |
包装: | 5mg |
市场价: | 4050元 |
Cas No. | 2139287-33-3 |
分子式 | C40H52N8O10S2 |
分子量 | 869.02 |
溶解度 | DMSO : 100 mg/mL (115.07 mM; Need ultrasonic) |
储存条件 | Store at -20°C, stored under nitrogen |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | THAL-SNS-032 is a selective CDK9 degrader PROTAC consisting of a CDK-binding SNS-032 ligand linked to a thalidomide derivative that binds the E3 ubiquitin ligase Cereblon (CRBN)[1]. THAL-SNS-032 selectively induces degradation of CDK9[1].THAL-SNS-032 diminishes elongating polymerase II[1].THAL-SNS-032 inhibits proliferation of MOLT4 cells with an IC50 of 50 nM[1]. [1]. Olson CM,et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2018 Feb;14(2):163-170. |