| 包装: | 100mM (in 1mL Water) |
| 市场价: | 34560元 |
| 别名 | 2′,3′-Dideoxyguanosine 5′-triphosphate trisodium |
| 分子式 | C10H13N5Na3O12P3 |
| 分子量 | 557.13 |
| 储存条件 | -20°C, away from moisture |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | ddGTP (2′,3′-Dideoxyguanosine 5′-triphosphate) trisodium is one of 2',3'-dideoxyribonucleoside 5'-triphosphates (ddNTPs) that acts as chain-elongating inhibitor of DNA polymerase for DNA sequencing. ddGTP trisodium acts as an inhibitor or a substrate for DNA polymerase α[1][2][3]. ddGTP trisodium inhibits the formation of both negative and positive DNA strands[1].ddGTP trisodium inhibits DNA polymerase α activity in the presence of Mn[2+] at low concentrations (<1 μM) [2]. ddGTP trisodium competitively inhibits the incorporation of [3H]dGTP into the DNA[2]. [1]. Debyser Z, et al. Kinetics of inhibition of endogenous human immunodeficiency virus type 1 reverse transcription by 2',3'-dideoxynucleoside 5'-triphosphate, tetrahydroimidazo-[4,5,1-jk][1,4]-benzodiazepin-2(1H)-thion e, and 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine derivatives. J Biol Chem. 1992 Jun 15;267(17):11769-76. |
m.cnreagent.com