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CDK4/6-IN-6
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CDK4/6-IN-6图片
CAS NO:2380321-51-5
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
CDK4/6-IN-6 (example A94) 是一种有效的 CDK4/CDK6 抑制剂，对CDK4/Cyclin D1 和 CDK6/Cyclin D3 的 Ki 值为 0.6 nM 和 13.9 nM。
Cas No.2380321-51-5
分子式C22H27ClFN5O3
分子量463.93
溶解度DMSO : 250 mg/mL (538.87 mM; Need ultrasonic)
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CDK4/6-IN-6 (example A94) is a potent CDK4/CDK6 inhibitor with a Ki of 0.6 nM and 13.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively[1].

CDK4/6-IN-6 (example A94) has IC50s of 38.5 nM and 144.9 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3 using phospho-Rb S795 ELISA assays in JEKO-1 and MV4-1 1 cells[1].

[1]. Ping Chen, et al. 2-amino-pyridine or 2-amino-pyrimidine derivatives as cyclin dependent kinase inhibitors. WO2019207463A1.