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CB-096
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CB-096图片
CAS NO:108883-90-5
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议
250mg电议

产品介绍
An inhibitor of RAN translation
Cas No.108883-90-5
Canonical SMILESOC(C=CC(C(NC1=C2)=NC1=CC=C2[N+]([O-])=O)=C3)=C3OC
分子式C14H11N3O4
分子量285.3
溶解度DMF: 14 mg/mL,DMSO: 20 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 0.3 mg/mL
储存条件-20буC
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CB-096 is an inhibitor of repeat-associated non-ATG (RAN) translation.1It selectively binds to the hexanucleotide GGGGCC repeat expansion (r(G4C2)exp) hairpin r(G4C2)8(EC50= 19 µM) over the anti-sense hairpin r(G2C4)8and base-paired construct r(GGCC)10. CB-096 (25 µM) inhibits RAN translation and the formation of nuclear stress granules in HEK293T cells expressing r(G4C2)66in anin vitromodel ofC9orf72amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) (c9ALS/FTD). It also induces relaxation of rat thoracic aortic rings pre-contracted with norepinephrine (EC50= 1.81 µM) and decreases systolic arterial pressure in conscious spontaneously hypertensive rats when administered at a dose of 100 mg/kg.2

1.Ursu, A., Wang, K.W., Bush, J.A., et al.Structural features of small molecules targeting the RNA repeat expansion that causes genetically defined ALS/FTDACS Chem. Biol.15(12)3112-3123(2020) 2.Navarrete-VÁzquez, G., Hidalgo-Figueroa, S., Torres-Piedra, M., et al.Synthesis, vasorelaxant activity and antihypertensive effect of benzo[d]imidazole derivativesBioorg. Med. Chem.18(11)3985-3991(2010)