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Stercobilin(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Stercobilin(hydrochloride)图片
CAS NO:5370-34-3
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
A fecal pigment and metabolite of bilirubin
Cas No.5370-34-3
Canonical SMILESOC(CCC1=C(C)C(C[C@@H]2NC([C@H](CC)[C@H]2C)=O)=N/C1=C\C3=C(CCC(O)=O)C(C)=C(C[C@@H]4NC([C@H](C)[C@H]4CC)=O)N3)=O.Cl
分子式C33H46N4O6 • XHCl
分子量594.8
溶解度DMF: soluble,NaOH (aq): soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Stercobilin is a fecal pigment and a metabolite of the heme catabolite bilirubin .1It induces DNA damage in a comet assay in HepG2 cells when used at concentrations ranging from 0.5 to 17 µM.2Stercobilin (20 and 30 µM) induces activation of NF-κB in a reporter assay and increases the expression of the genes encoding TNF-α, IL-1β, IL-6, inducible nitric oxide synthase (iNOS), and COX-2 in RAW 264.7 macrophages.3Fecal and plasma levels of stercobilin are increased inob/obmice.

1.VÍtek, L., Majer, F., MuchovÁ, L., et al.Identification of bilirubin reduction products formed by Clostridium perfringens isolated from human neonatal fecal floraJ. Chromatogr. B Analyt. Technol. Biomed. Life Sci.833(2)149-157(2006) 2.MÖlzer, C., Pfleger, B., Putz, E., et al.In vitro DNA-damaging effects of intestinal and related tetrapyrroles in human cancer cellsExp. Cell Res.319(4)536-545(2013) 3.Sanada, S., Suzuki, T., Nagata, A., et al.Intestinal microbial metabolite stercobilin involvement in the chronic inflammation of ob/ob miceSci. Rep.10(1)6479(2020)