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HQ461
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HQ461图片
CAS NO:1226443-41-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
HQ461 是一种分子胶 (molecular glue),可促进 CDK12-DDB1 相互作用以触发 cyclin K 降解。 HQ461 介导的 cyclin K 降解损害 CDK12 功能,导致 CDK12 底物磷酸化降低、DNA 损伤反应基因下调和细胞死亡。
Cas No.1226443-41-9
分子式C15H15N5OS2
分子量345.44
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation. HQ461-mediated degradation of cyclin K impairs CDK12 function, resulting in decreased CDK12 substrate phosphorylation, downregulation of DNA damage response genes, and cell death[1].

[1]. Lv L, et al. Discovery of a molecular glue promoting CDK12-DDB1 interaction to trigger cyclin K degradation. Elife. 2020 Aug 17;9:e59994.