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1-Ethyl-1-nitrosourea(hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
1-Ethyl-1-nitrosourea(hydrate)图片
包装与价格:
包装价格(元)
1 g电议
5 g电议
10 g电议
25 g电议

产品介绍
A DNA alkylating agent
Canonical SMILESO=NN(CC)C(N)=O
分子式C3H7N3O2• XH2O
分子量117.1
溶解度DMF: 15 mg/mL,DMSO: 20 mg/mL,Ethanol: 20 mg/mL,PBS (pH 7.2): 3 mg/mL
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

1-Ethyl-1-nitrosourea (ENU) is a DNA alkylating agent.1It increases the concentrations of O6-ethylguanine, N7-ethylguanine, N7-ethyladenine, and N3-ethyladenine in rat brain. ENU (80 mg/kg) is teratogenicin vivo, inducing tumor formation and paw malformations in rat pups when administered to pregnant rats.2

1.Goth, R., and Rajewsky, M.F.Persistence of O6-ethylguanine in rat-brain DNA: Correlation with nervous system-specific carcinogenesis by ethylnitrosoureaProc. Natl. Acad. Sci. USA71(3)639-643(1974) 2.Druckrey, H., Ivankovi?, S., and Preussmann, R.Teratogenic and carcinogenic effects in the offspring after single injection of ethylnitrosourea to pregnant ratsNature210(5043)1378-1379(1966)