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Wee1 Inhibitor
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Wee1 Inhibitor图片
CAS NO:622855-37-2
包装:1mg
市场价:1530元

产品介绍
Wee1 Inhibitor 是一种有效的检查点 Wee1 激酶抑制剂,IC50 为 0.011 μM。
Cas No.622855-37-2
Canonical SMILESOC1=CC=C(N([H])C2=C3C4=C(C(N([H])C4=O)=O)C(C5=C(Cl)C=CC=C5)=C2)C3=C1
分子式C20H11ClN2O3
分子量362.8
溶解度DMSO: 10 mg/ml,Ethanol: 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Wee1 inhibitor is an inhibitor of the checkpoint kinase Wee1 (IC50= 11 nM).1It is selective for Wee1 over checkpoint kinase 1 (Chk1; IC50= 440 nM). Wee1 inhibitor also inhibits the ATPase activity of LptB, an enzyme involved in the transport and assembly of LPS (IC50= 25 µM for theE. colienzyme).2

1.Palmer, B.D., Thompson, A.M., Booth, R.J., et al.4-Phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione inhibitors of the checkpoint kinase Wee1. Structure-activity relationships for chromophore modification and phenyl ring substitutionJ. Med. Chem.49(16)4896-4911(2006) 2.Gronenberg, L.S., and Kahne, D.Development of an activity assay for discovery of inhibitors of lipopolysaccharide transportJ. Am. Chem. Soc.132(8)2518-2519(2010)