CAS NO: | 106972-44-5 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
Cas No. | 106972-44-5 |
别名 | L-亮氨酸 d10 |
Canonical SMILES | [2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[C@@](N)([2H])C(O)=O |
分子式 | C6H3D10NO2 |
分子量 | 141.2 |
溶解度 | PBS (pH 7.2): 1 mg/ml |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | L-Leucine-d10is intended for use as an internal standard for the quantification of L-leucine by GC- or LC-MS. L-Leucine is an essential amino acid.1It increases basal insulin secretion and decreases glucose-induced insulin release in INS-1E rat insulinoma cells when used at concentrations of 1, 5, and 10 mM.2L-Leucine (1, 5, and 10 mM) decreases triglyceride levels and increases cholesterol accumulation in INS-1E cells. It stimulates skeletal muscle protein synthesis in exercised rats, as well as in food-deprived rats in an mTOR-dependent manner.3,4Formulations containing L-leucine have been used as dietary supplements. 1.Duan, Y., Li, F., Li, Y., et al.The role of leucine and its metabolites in protein and energy metabolismAmino Acids48(1)41-51(2016) 2.Liu, Z., Jeppesen, P.B., Gregersen, S., et al.Chronic exposure to leucine in vitro induces β-cell dysfunction in INS-1E cells and mouse isletsJ. Endocrinol.215(1)79-88(2012) 3.Anthony, J.C., Yoshizawa, F., Anthony, T.G., et al.Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathwayJ. Nutr.130(10)2413-2419(2000) 4.Anthony, J.C., Anthony, T.G., and Layman, D.K.Leucine supplementation enhances skeletal muscle recovery in rats following exerciseJ. Nutr.129(6)1102-1106(1999) |