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L-Leucine-d10
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
L-Leucine-d10图片
CAS NO:106972-44-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
An internal standard for the quantification of L-leucine
Cas No.106972-44-5
别名L-亮氨酸 d10
Canonical SMILES[2H]C([2H])([2H])C(C([2H])([2H])[2H])([2H])C([2H])([2H])[C@@](N)([2H])C(O)=O
分子式C6H3D10NO2
分子量141.2
溶解度PBS (pH 7.2): 1 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

L-Leucine-d10is intended for use as an internal standard for the quantification of L-leucine by GC- or LC-MS. L-Leucine is an essential amino acid.1It increases basal insulin secretion and decreases glucose-induced insulin release in INS-1E rat insulinoma cells when used at concentrations of 1, 5, and 10 mM.2L-Leucine (1, 5, and 10 mM) decreases triglyceride levels and increases cholesterol accumulation in INS-1E cells. It stimulates skeletal muscle protein synthesis in exercised rats, as well as in food-deprived rats in an mTOR-dependent manner.3,4Formulations containing L-leucine have been used as dietary supplements.

1.Duan, Y., Li, F., Li, Y., et al.The role of leucine and its metabolites in protein and energy metabolismAmino Acids48(1)41-51(2016) 2.Liu, Z., Jeppesen, P.B., Gregersen, S., et al.Chronic exposure to leucine in vitro induces β-cell dysfunction in INS-1E cells and mouse isletsJ. Endocrinol.215(1)79-88(2012) 3.Anthony, J.C., Yoshizawa, F., Anthony, T.G., et al.Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathwayJ. Nutr.130(10)2413-2419(2000) 4.Anthony, J.C., Anthony, T.G., and Layman, D.K.Leucine supplementation enhances skeletal muscle recovery in rats following exerciseJ. Nutr.129(6)1102-1106(1999)