您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Carboplatin-d4
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Carboplatin-d4
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Carboplatin-d4图片
包装:1mg
市场价:2706元

产品介绍
卡铂-d4 (NSC 241240-d4) 是氘标记的卡铂。 Carboplatin (NSC 241240) 是一种 DNA 合成抑制剂,可与 DNA 结合,抑制复制和转录并诱导细胞死亡。 Carboplatin (NSC 241240) 是 CDDP 的衍生物,是一种有效的抗癌剂。
别名NSC 241240-d4
Canonical SMILESO=C([O-][Pt+2]1([NH3])[NH3])C2(C([2H])([2H])CC2([2H])[2H])C([O-]1)=O
分子式C6H8D4N2O4Pt
分子量375.3
溶解度Methanol: slightly soluble,Water: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Carboplatin-d4is intended for use as an internal standard for the quantification of carboplatin by GC- or LC-MS. Carboplatin is a platinum-containing DNA-crosslinking agent.1It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks when used at concentrations of 200 and 300 µM. It inhibits the proliferation of GLC-4 small cell lung carcinoma and A2780 and SKOV3 ovarian cancer cells (IC50s = 22.7, 0.5, and 10.2 µM, respectively).2,3Carboplatin reduces tumor growth in an ADJ/PC6 murine plasmacytoma model (ED90= 0.6 mg/kg, i.p.).4Formulations containing carboplatin have been used in the treatment of ovarian cancer.

1.Micetich, K.C., Barnes, D., and Erickson, L.C.A comparative study of the cytotoxicity and DNA-damaging effects of cis-(diammino)(1,1-cyclobutanedicarboxylato)-platinum(II) and cis-diamminedichloroplatinum(II) on L1210 cellsCancer Res.45(9)4043-4047(1985) 2.Groen, H.J., Sleijfer, S., Meijer, C., et al.Carboplatin- and cisplatin-induced potentiation of moderate-dose radiation cytotoxicity in human lung cancer cell linesBr. J. Cancer72(6)1406-1411(1995) 3.Al-Eisawi, Z., Beale, P., Chan, C., et al.Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour modelsJ. Ovarian Res.6(1)78(2013) 4.Kelland, L.R., Abel, G., McKeage, M.J., et al.Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): An orally active platinum drugCancer Res.53(11)2581-2586(1993)