| 包装: | 1mg |
| 市场价: | 2706元 |
| 别名 | NSC 241240-d4 |
| Canonical SMILES | O=C([O-][Pt+2]1([NH3])[NH3])C2(C([2H])([2H])CC2([2H])[2H])C([O-]1)=O |
| 分子式 | C6H8D4N2O4Pt |
| 分子量 | 375.3 |
| 溶解度 | Methanol: slightly soluble,Water: slightly soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Carboplatin-d4is intended for use as an internal standard for the quantification of carboplatin by GC- or LC-MS. Carboplatin is a platinum-containing DNA-crosslinking agent.1It induces the formation of DNA interstrand crosslinks and DNA-protein crosslinks when used at concentrations of 200 and 300 µM. It inhibits the proliferation of GLC-4 small cell lung carcinoma and A2780 and SKOV3 ovarian cancer cells (IC50s = 22.7, 0.5, and 10.2 µM, respectively).2,3Carboplatin reduces tumor growth in an ADJ/PC6 murine plasmacytoma model (ED90= 0.6 mg/kg, i.p.).4Formulations containing carboplatin have been used in the treatment of ovarian cancer. 1.Micetich, K.C., Barnes, D., and Erickson, L.C.A comparative study of the cytotoxicity and DNA-damaging effects of cis-(diammino)(1,1-cyclobutanedicarboxylato)-platinum(II) and cis-diamminedichloroplatinum(II) on L1210 cellsCancer Res.45(9)4043-4047(1985) 2.Groen, H.J., Sleijfer, S., Meijer, C., et al.Carboplatin- and cisplatin-induced potentiation of moderate-dose radiation cytotoxicity in human lung cancer cell linesBr. J. Cancer72(6)1406-1411(1995) 3.Al-Eisawi, Z., Beale, P., Chan, C., et al.Carboplatin and oxaliplatin in sequenced combination with bortezomib in ovarian tumour modelsJ. Ovarian Res.6(1)78(2013) 4.Kelland, L.R., Abel, G., McKeage, M.J., et al.Preclinical antitumor evaluation of bis-acetato-ammine-dichloro-cyclohexylamine platinum(IV): An orally active platinum drugCancer Res.53(11)2581-2586(1993) |
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