您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > PI3Kγ inhibitor 1
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
PI3Kγ inhibitor 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PI3Kγ inhibitor 1图片
CAS NO:1172118-03-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议

产品介绍
PI3Kγ inhibitor 1 是一种 PI3Kδ 和 PI3Kγ 抑制剂,详细信息请参考专利文献 WO2014004470A1 中 Table 4 中的化合物 168。PI3Kγ inhibitor 1 抑制 PI3Kδ 和 PI3Kγ,IC50<100 nM。
Cas No.1172118-03-4
别名PI3K纬INHIBITOR1
Canonical SMILESO=C1N(C2=CC=CC=C2C)C(CN3N=C(C4=CC=C(N=C(NC(C)=O)S5)C5=C4)C6=C3N=CN=C6N)=CC7=CC=CC(C)=C71
分子式C32H26N8O2S
分子量586.67
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PI3Kγ inhibitor 1 is a PI3Kδ and PI3Kγ inhibitor extracted from patent WO2014004470A1, Compound 168 in Table 4, has IC50s of<100 nM. PI3Kδ|100 nM (IC50)|PI3Kγ|100 nM (IC50)|PI3Kα|10 μM (IC50)|PI3Kβ|10 μM (IC50)

In Table 3, PI3Kγ inhibitor 1 (Compound 168) inhibits PI3Kδ, PI3Kγ, PI3Kα and PI3Kβ with IC50s of<100 nM,<100 nM,<10 μM and<10 μM, respectively. PI3Kγ inhibitor 1 inhibits B cell proliferation with an EC50<100 nM.

[1]. Vito J. Palombella, et al. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using pi3 kinase inhibitors. WO 2014004470 A1.