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Crebanine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Crebanine图片
CAS NO:25127-29-1
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Crebanine 是来自于 Stephania venosa 的一种生物碱,可诱导人类癌细胞的 G1阻滞和凋亡。Crebanine 通过抑制 MAPKs 和 Akt 信号通路表现出抗炎活性。Crebanine 还具有抗心律失常的作用。
Cas No.25127-29-1
别名克班宁
Canonical SMILESCN1CCC(C2=C3C4=CC=C(OC)C(OC)=C4C[C@@]12[H])=CC5=C3OCO5
分子式C20H21NO4
分子量339.39
溶解度Soluble in DMSO
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Crebanine, an alkaloid from Stephania venosa, induces G1 arrest and apoptosis in human cancer cells. Crebanine exhibits anti-inflammatory activity via suppressing MAPKs and Akt signaling. Crebanine also possesses antiarrhythmic effect[1][2].

[1]. Wongsirisin P, et al. Induction of G1 arrest and apoptosis in human cancer cells by crebanine, an alkaloid from Stephania venosa. Chem Pharm Bull (Tokyo). 2012;60(10):1283-9. [2]. Intayoung P, et al. Antiinflammatory Activities of Crebanine by Inhibition of NF-κB and AP-1 Activation through Suppressing MAPKs and Akt Signaling in LPS-Induced RAW264.7 Macrophages. Biol Pharm Bull. 2016;39(1):54-61.