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Cysmethynil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cysmethynil图片
CAS NO:851636-83-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Cas No.851636-83-4
Canonical SMILESCCCCCCCCN1C2=CC=C(C3=CC(C)=CC=C3)C=C2C(CC(N)=O)=C1
分子式C25H32N2O
分子量376.5
溶解度DMF: 3.3 mg/ml,DMSO: 5 mg/ml,Ethanol: 20 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Post-translational protein prenylation is a 3-step process that occurs at the C-terminus of a number of proteins involved in cell growth control and oncogenesis. Isoprenylcysteine carboxyl methyltransferase (Icmt) catalyzes the methylation of C-terminal prenylcysteine residues, the last step in this process. Cysmethynil is an indole-based, time-dependent inhibitor of Icmt (IC50 = adenosylmethionine (Ki = 0.14 µM for the final complex). It does not inhibit other enzymes in the prenylation pathway (farensyltransferase, geranylgeranyltransferase type I, and Rce1) at concentrations up to 50 µM, or related methyltransferases. Treatment of cancer cells results in a dose-dependent decrease in Ras carboxylmethylation, mislocalization of Ras, and impaired signaling through Ras pathways. Treatment of PC3 prostate cancer cells with 25 µM cysmethynil resulted in decreased mTOR signaling, accumulation of cells in the G1 phase, and autophagy-mediated cell death.