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17β-hydroxy Wortmannin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
17β-hydroxy Wortmannin图片
CAS NO:58053-83-1
包装与价格:
包装价格(元)
500μg电议
1mg电议
5mg电议
10mg电议

产品介绍
17β-hydroxy Wortmannin is an analog of wortmannin.
Cas No.58053-83-1
Canonical SMILESO=C(C1=CO2)O[C@H](COC)[C@@]3(C)C1=C2C(C4=C3[C@H](OC(C)=O)C[C@@]5(C)[C@@]4([H])CC[C@@H]5O)=O
分子式C23H26O8
分子量430.4
溶解度DMF: 3 mg/ml,DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml,DMSO: 2.5 mg/ml,Ethanol: 0.15 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

17β-hydroxy Wortmannin is an analog of wortmannin. It irreversibly binds phosphoinositide 3-kinase (PI3K) and potently blocks fMLP-stimulated respiratory burst in neutrophils (IC50 = 5 nM). 17β-hydroxy Wortmannin inhibits recombinant PI3K and mTOR (IC50 = 2.7 and 193 nM, respectively) and prevents the growth of LNCap prostate cancer cells (IC50 = 1.46 μM). The 17-hydroxyl group has been used to further modify this compound, e.g., by pegylation and conjugation with rapamycin.