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2,3-Dimethoxy-5-methyl-p-benzoquinone
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2,3-Dimethoxy-5-methyl-p-benzoquinone图片
CAS NO:605-94-7
包装与价格：
包装价格(元)
1g电议
5g电议
10g电议
25g电议

产品介绍
2,3-Dimethoxy-5-methyl-p-benzoquinone (CoQ0) 是一种有效的口服活性泛醌化合物，可以从牛樟芝中提取。
Cas No.605-94-7
别名2,3-二甲氧基-5-甲基-1,4-苯醌,CoQ0
Canonical SMILESO=C(C(C)=C1)C(OC)=C(OC)C1=O
分子式C9H10O4
分子量182.2
溶解度DMF: 100 mg/ml,DMSO: 100 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 0.2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2,3-Dimethoxy-5-methyl-p-benzoquinone, also known as coenzyme Q0, is a key intermediate in the synthesis of coenzyme Q, coenzyme Q10, other ubiquinones, and vitamin E. It inhibits the growth of SKOV-3, A2780, and A2870/CP70 human ovarian carcinoma cells (IC50s = 26.6, 27.3, and 28.4 µM, respectively) with a cytotoxic concentration of greater than 40 µM for non-cancerous ovarian surface epithelial cells. It halts the cell cycle at the G2/M phase, increases the production of reactive oxygen species (ROS), and induces autophagy and apoptosis in SKOV-3 cells. 2,3-Dimethoxy-5-methyl-p-benzoquinone downregulates the protooncogene HER-2 and decreases the protein levels of phosphorylated AKT and mTOR in SKOV-3 cells. It also decreases the incidence of tumors and tumor burden in a SKOV-3 human ovarian carcinoma mouse xenograft model when administered at a dose of 2.5 mg/kg every four days.