您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > (R)-Nedisertib
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
(R)-Nedisertib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(R)-Nedisertib图片
CAS NO:1637542-32-5
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
(R)-Nedisertib((R)-M3814)是一种活性较弱的Nedisertib的R型异构体,对DNA-PK的IC50值为7-30nM。
Cas No.1637542-32-5
Canonical SMILESClC1=C([C@@H](O)C2=NN=C(OC)C=C2)C=C(C3=C4C=CC(N5CCOCC5)=CC4=NC=N3)C(F)=C1
分子式C24H21ClFN5O3
分子量481.91
溶解度DMSO : 100 mg/mL (207.51 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK[1]. DNA-PK|7-30 nM (IC50)

Rac-Nedisertib (Compound 135) less actively inhibits DNA-PK, with an IC50 in the range of 7-30 nM[1].

[1]. Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.