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UNC0642
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
UNC0642图片
CAS NO:1481677-78-4
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品名称
UNC 0642, UNC-0642
产品介绍

生物活性

UNC0642是有效的选择性G9a和GLP组蛋白赖氨酸甲基转移酶抑制剂(IC50 <2.5 nM)。它降低了MDA-MB-231细胞中的H3K9二甲基化水平(IC50 = 110 nM)。在体内显示适度的大脑渗透。

化学数据

目录号A15487
作用机制Inhibitor (抑制剂)
M. Wt546.69
FormulaC29H44F2N6O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1481677-78-4
SynonymsUNC 0642, UNC-0642
SMILESCC(C)N1CCC(CC1)NC2=NC(=NC3=CC(=C(C=C32)OC)OCCCN4CCCC4)N5CCC(CC5)(F)F

溶解度

In vitroDMSO88 mg/mL (160.96 mM)
WaterInsoluble
Ethanol88 mg/mL (160.96 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM18.29 mL91.46 mL182.92 mL
0.5 mM3.66 mL18.29 mL36.58 mL
1 mM1.83 mL9.15 mL18.29 mL
5 mM0.37 mL1.83 mL3.66 mL

*The above data is based on the productmolecular weight 546.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.