| CAS NO: | 32703-82-5 |
| 包装 | 价格(元) |
| 1g | 电议 |
| 5g | 电议 |
| Cas No. | 32703-82-5 |
| 别名 | 6-叔丁基-2,3-二氰基萘 |
| Canonical SMILES | N#CC1=CC2=CC=C(C(C)(C)C)C=C2C=C1C#N |
| 分子式 | C16H14N2 |
| 分子量 | 234.3 |
| 溶解度 | Chloroform: 10 mg/ml,DMF: 1 mg/ml,DMF:PBS (pH 7.2) (1:2): 0.33 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | BRD9876 is an inhibitor of the kinesin spindle protein Eg5.1It arrests Eg5-mediated microtubule gliding, as well as inhibits Eg5 ATPase activity in the presence of microtubules, in cell-free assays. BRD9876 is cytotoxic to MM.1S stroma-independent multiple myeloma cells (IC50= 2.2 µM). It induces cell cycle arrest at the G2/M phase in MM.1S cells when used at a concentration of 10 µM. 1.Chattopadhyay, S., Stewart, A.L., Mukherjee, S., et al.Niche-based screening in multiple myeloma identifies a kinesin-5 inhibitor with improved selectivity over hematopoietic progenitorsCell Rep.10(5)755-770(2015) |
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