Propiconazole-d₇is intended for use as an internal standard for the quantification of propiconazole by GC- or LC-MS. Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption.¹It inhibitsS. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC₅₀s = 0.04 and >200 µM, respectively).²Propiconazole inhibits the growth ofT. deformansandR. stolonifer(EC₅₀s = 0.073 and 4.6 µg/ml, respectively), as well asA. niger,M. fructigena,S. nodorum,T. harzanium,R. solani, andS. rolfsiiat concentrations ranging from 0.1 to 5 ppm.³It increases the weight of seminal vesicles and vas deferens, as well as the percentage of sperm with abnormal tail morphology, and decreases the plasma concentration of estradiol in male rats when administered at a dose of 4 mg/kg.⁴Propiconazole increases production of reactive oxygen species (ROS), the number of DNA mutations, and the incidence of tumor formation in mouse liver.⁵Formulations containing propiconazole have been used in the control of fungi in agriculture.

1.Zarn, J.A., BrÜschweiler, B.J., and Schlatter, J.R.Azole fungicides affect mammalian steroidogenesis by inhibiting sterol 14 α-demethylase and aromataseEnviron. Health Perspect.111(3)255-261(2003) 2.Vanden Bossche, H., Lauwers, W., Willemsens, G., et al.Molecular basis for the antimycotic and antibacterial activity of N-substituted imidazoles and triazoles: The inhibition of isoprenoid biosynthesisPestic. Sci.15(2)188-198(1984) 3.Sancholle, M., Weete, J.D., and Montani, C.Effects of triazoles on fungi: I. Growth and cellular permeabilityPest. Biochem. Phys.21(1)31-44(1984) 4.Costa, N.O., Vieira, M.L., Sgarioni, V., et al.Evaluation of the reproductive toxicity of fungicide propiconazole in male ratsToxicology33555-61(2015) 5.Nesnow, S.Integration of toxicological approaches with "omic" and related technologies to elucidate mechanisms of carcinogenic action: Propiconazole, an exampleCancer Lett.334(1)20-27(2013)