| CAS NO: | 1129540-33-5 |
| 包装: | 1mg |
| 市场价: | 5670元 |
| Cas No. | 1129540-33-5 |
| 别名 | 紫杉醇 d5 |
| Canonical SMILES | O=C([C@H](OC(C)=O)C1=C(C)[C@@H](OC([C@H](O)[C@@H](NC(C2=C([2H])C([2H])=C([2H])C([2H])=C2[2H])=O)C3=CC=CC=C3)=O)C[C@]([C@H]4OC(C5=CC=CC=C5)=O)(O)C1(C)C)[C@@]6(C)[C@@]4([H])[C@@]7(OC(C)=O)[C@H](OC7)C[C@@H]6O |
| 分子式 | C47H46D5NO14 |
| 分子量 | 859 |
| 溶解度 | Chloroform: Slightly Soluble,Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Paclitaxel-d5contains five deuterium atoms. It is intended for use as an internal standard for the quantification of paclitaxel using GC- or LC-MS. Paclitaxel is cytotoxic against a variety of cancer cell lines with IC50values ranging from 2.5-7.5 nM.1It disrupts multipolar spindle formation, inducing cell cycle arrest in various human cell cancer lines (IC50s = 6.7-18.5 nM) at both prophase and G1.2It also initiates apoptosis of cancer cells through multiple mechanisms involving p53-dependent and -independent pathways, Bcl-2 family members, cyclin-dependent kinases, and c-Jun N-terminal kinases/stress-activated protein kinases.3 1.Liebmann, J.E., Cook, J.A., Lipschultz, C., et al.Cytotoxic studies of paclitaxel (Taxol) in human tumour cell linesBr. J. Cancer68(6)1104-1109(1993) 2.Woods, C.M., Zhu, J., McQueney, P.A., et al.Taxol-induced mitotic block triggers rapid onset of a p53-independent apoptotic pathwayMol. Med.1(5)506-526(1995) 3.Wang, T.h., Wang, H.S., and Soong, Y.K.Paclitaxel-induced cell death: Where the cell cycle and apoptosis come togetherCancer88(11)2619-2628(2000) |
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