| CAS NO: | 1217680-57-3 |
| 包装 | 价格(元) |
| 500 μg | 电议 |
| 1mg | 电议 |
| Cas No. | 1217680-57-3 |
| Canonical SMILES | COC1=C2C(CCN([13C]([2H])([2H])[2H])[C@@]2([H])[C@]3([H])C(C=CC(OC)=C4OC)=C4C(O3)=O)=CC5=C1OCO5 |
| 分子式 | C21[13C]H20D3NO7 |
| 分子量 | 417.4 |
| 溶解度 | DMSO: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Noscapine-13C-d3is intended for use as an internal standard for the quantification of noscapine by GC- or LC-MS. Noscapine is an alkaloid that has been found in opium and has anticancer and antitussive properties.1,2,3It binds to tubulin and induces cell cycle arrest at the G2/M phase in HeLa cells when used at a concentration of 20 µM.2Noscapine induces apoptosis in HeLa cells and thymocytes (IC50s = 25 and 10 µM, respectively) and reduces proliferation of MCF-7 breast and Renal 1983 bladder cancer cells (IC50s = 42.3 and 39.1 µM, respectively).In vivo, noscapine (120 mg/kg) induces tumor regression in an MCF-7 mouse xenograft model. Noscapine (30 and 70 mg/kg) decreases the number of citric acid-induced coughs in guinea pigs.3 1.Kingston, D.G.I.Tubulin-interactive natural products as anticancer agentsJ. Nat. Prod.72(3)507-515(2009) 2.Ye, K., Ke, Y., Keshava, N., et al.Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cellsProc. Nat. Acad. Sci. U.S.A.95(4)1601-1606(1998) 3.Idaan-Heikkila, J.E., Jalonen, K., and Vartiainen, A.Evaluation of the antitussive effect of noscapine and codeine on citric acid cough in guinea-pigsActa. Pharmacol. Toxicol. (Copenh)25(3)333-338(1967) |
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