| CAS NO: | 1217651-73-4 |
| 包装: | 1mg |
| 市场价: | 4763元 |
| Cas No. | 1217651-73-4 |
| 别名 | 秋水仙素 d6 |
| Canonical SMILES | COC1=C(OC)C(OC)=CC2=C1C(C([C@@H](NC(C([2H])([2H])[2H])=O)CC2)=C3)=CC=C(OC([2H])([2H])[2H])C3=O |
| 分子式 | C22H19D6NO6 |
| 分子量 | 405.5 |
| 溶解度 | Chloroform: Slightly Soluble,Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Colchicine-d6is intended for use as an internal standard for the quantification of colchicine by GC- or LC-MS. Colchicine is an inhibitor of microtubule polymerization (IC50= 3.2 μM) that binds to tubulin, which disrupts spindle formation during mitosis.1It inhibits growth of MCF-7 human breast carcinoma cells with an IC50value of 13 nM.1Colchicine has anti-inflammatory activity, inhibiting neutrophil motility and activity when used at a dose of 5 μmol/kg in a mouse model of gout and preventing the deposition of uric acid.2,3 1.Martino, G.D., Regina, G.L., Coluccia, A., et al.Arylthioindoles, potent inhibitors of tubulin polymerizationJ. Med. Chem.47(25)6120-6123(2004) 2.McCarty, D.J.Urate crystals, inflammation, and colchicineArthritis Rheum.58(2)S20-S24(2008) 3.Chia, E.W., Grainger, R., and Harper, J.L.Colchicine suppresses neutrophil superoxide production in a murine model of gouty arthritis: A rationale for use of low-dose colchicineBr. J. Pharmacol.153(6)1288-1295(2008) |
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