| CAS NO: | 1023650-66-9 |
PF-03882845 is a potent non-steroidal mineralocorticoid antagonist with and IC50of 0.755 nM, compared to eplerenone with an IC50of 109 nM. PF-03882845 was tested in a rat model for renal protection against aldosterone-mediated renal disease, and found to be more potent than eplerenone in suppressing the urinary albumin to creatinine ratio (UACR), a measure of renal fibrosis. The therapeutic index, calculated as the ratio of the EC50for increasing serum K+ to the EC50for UACR lowering, was 83.8 for PF-03882845 and 1.47 for eplerenone.
| 分子量 | 419.9 |
| 分子式 | C24H22ClN3O2 |
| CAS号 | 1023650-66-9 |
| 纯度 | >98% |
| 溶解性（25°C） | DMSO: 10 mg/mL clear |
| 储存和运输条件 | 固体粉末： -20°C 冷藏长期储存 常温运输及临时存放 |
| 小鼠 | 大鼠 | 兔 | 豚鼠 | 仓鼠 | 狗 | |
| 重量 (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| 体表面积 (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km系数 | 3 | 6 | 12 | 8 | 5 | 20 |
| 动物 A (mg/kg) = 动物 B (mg/kg) × | 动物 B的Km系数 |
| 动物 A的Km系数 |
例如，依据体表面积折算法，将化合物用于小鼠的剂量20 mg/kg 换算成大鼠的剂量，需要将20 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到化合物用于大鼠的等效剂量为10 mg/kg。
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.3815 mL | 11.9076 mL | 23.8152 mL |
| 5 mM | 0.4763 mL | 2.3815 mL | 4.763 mL |
| 10 mM | 0.2382 mL | 1.1908 mL | 2.3815 mL |
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