| CAS NO: | 13192-04-6 |
| 包装 | 价格(元) |
| 500mg | 电议 |
| 1 g | 电议 |
| 5 g | 电议 |
| Cas No. | 13192-04-6 |
| 别名 | alpha-酮戊二酸二甲酯 |
| Canonical SMILES | COC(CCC(C(OC)=O)=O)=O |
| 分子式 | C7H10O5 |
| 分子量 | 174.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dimethyl 2-ketoglutarate is an esterified form of the citric acid cycle intermediate α-ketoglutarate.1It increases intracellular levels of α-ketoglutarate and decreases intracellular ATP levels in U2OS human osteosarcoma cells cultured in complete- or nutrient-free media when used at a concentration of 5 mM.2Dimethyl 2-ketoglutarate inhibits autophagy and decreases in intracellular levels of acetyl-CoA in serum- and nutrient-deprived cells.3It decreases cardiomyocyte hypertrophy in a mouse model of cardiac pressure overload induced by thoracic aortic constriction when administered at a dose of 300 mg/kg. Dimethyl 2-ketoglutarate reduces serum levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and hepatic fibrosis in a rat model of liver fibrosis induced by carbon tetrachloride (CCl4).1 1.Zhao, J., Peng, L., Cui, R., et al.Dimethyl α-ketoglutarate reduces CCl4-induced liver fibrosis through inhibition of autophagy in hepatic stellate cellsBiochem. Biophys. Res. Commun.481(1-2)90-96(2021) 2.Baracco, E.E., Castoldi, F., Durand, S., et al.α-Ketoglutarate inhibits autophagyAging (Albany NY)11(11)3418-3431(2021) 3.MariÑo, G., Pietrocola, F., Eisenberg, T., et al.Regulation of autophagy by cytosolic acetyl-coenzyme AMol. Cell53(5)710-725(2014) |
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