TFEB activator 1

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TFEB activator 1

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

39777-61-2

包装与价格：

包装	价格(元)
10mg	电议
25mg	电议
50mg	电议
100mg	电议

产品介绍

TFEB activator 1 是一种口服有效的，不依赖 mTOR 的 TFEB 激活剂。TFEB activator 1 显着促进 Flag-TFEB 的核易位，EC50 为 2167 nM。TFEB activator 1 在不抑制 mTOR 通路的情况下增强自噬 (autophagy)。TFEB activator 1 有潜力用于神经退行性疾病的研究。

Cas No.	39777-61-2
别名	(1E,4E)-1,5-二(2-甲氧基)-1,4-二烯基-3-戊酮,Curcumin analog C1
Canonical SMILES	O=C(/C=C/C1=CC=CC=C1OC)/C=C/C2=CC=CC=C2OC
分子式	C₁₉H₁₈O₃
分子量	294.34
溶解度	DMSO: 125 mg/mL (424.68 mM)
储存条件	Store at -20°C,unstable in solution, ready to use.
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1]. [1]. Song JX, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89.