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P62-mediated mitophagy inducer
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
P62-mediated mitophagy inducer图片
CAS NO:1809031-84-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
P62-mediated mitophagy inducer 是一种线粒体自噬调节剂,能激活线粒体噬但不招募 Parkin 或者使膜电位崩溃,且在缺乏完整功能的 PINK1/Parkin 通路的细胞中保留活性。
Cas No.1809031-84-2
别名PMI
Canonical SMILESO=[N+](C1=CC(C2=CN(C3=CC=CC(I)=C3)N=N2)=CC=C1)[O-]
分子式C14H9IN4O2
分子量392.15
溶解度DMSO: 1 mg/mL (2.55 mM; ultrasonic and adjust pH to 3 with 0.1 M HCL)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

P62-mediated mitophagy inducer is a mitophagy regulator which activates mitophagy without recruiting Parkin or collapsing δψm and retains activity in cells devoid of a fully functional PINK1/Parkin pathway[1].

[1]. East DA, et al. PMI: a δψm independent pharmacological regulator of mitophagy. Chem Biol. 2014 Nov 20;21(11):1585-96.