Liensinine Diperchlorate

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

5088-90-4

包装与价格：

包装	价格(元)
1mg	电议
5mg	电议
10mg	电议
20mg	电议
50mg	电议
100mg	电议

产品介绍

Liensinine Diperchlor?ate 是一种主要的异喹啉生物碱，从 Nelumbo nucifera Gaertn 的种子胚中提取。Liensinine Diperchlor?ate 通过阻断自噬小体-溶酶体融合来抑制晚期自噬 (autophagy/mitophagy)。Liensinine Diperchlor?ate 具有广泛的生物学活性，包括抗心律不齐，抗高血压，抗肺纤维化，血管平滑肌松弛等。

Cas No.	5088-90-4
别名	莲心碱高氯酸盐
Canonical SMILES	O=Cl(=O)(O)=O.CN1[C@@H](C2=CC(OC3=CC(C[C@@H]4C5=CC(OC)=C(OC)C=C5CCN4C)=CC=C3O)=C(OC)C=C2CC1)CC6=CC=C(O)C=C6.O=Cl(=O)(O)=O
分子式	C₃₇H₄₄Cl₂N₂O₁₄
分子量	811.66
溶解度	DMSO: 62.5 mg/mL (77.00 mM)
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Liensinine Diperchlor?ate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlor?ate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlor?ate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc[1]. [1]. Zhou J, et al. A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. Autophagy. 2015;11(8):1259-79.