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PF-06447475
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF-06447475图片
CAS NO:1527473-33-1
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议

产品名称
PF06447475, PF 06447475
产品介绍

生物活性

PF-06447475是一种高效,选择性,脑渗透性LRRK2抑制剂,对Wt LRRK2/G2019S LRRK2的IC50分别为3 nM/11 nM。

靶点信息

LRRK2G2019S LRRK2
3nM11nM

化学数据

目录号A15504
作用机制Inhibitor (抑制剂)
M. Wt305.33
FormulaC17H15N5O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1527473-33-1
SynonymsPF06447475, PF 06447475
SMILESC1COCCN1C2=NC=NC3=C2C(=CN3)C4=CC=CC(=C4)C#N

溶解度

In vitroDMSO56 mg/mL (183.4 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM32.75 mL163.76 mL327.51 mL
0.5 mM6.55 mL32.75 mL65.5 mL
1 mM3.28 mL16.38 mL32.75 mL
5 mM0.66 mL3.28 mL6.55 mL

*The above data is based on the productmolecular weight 305.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.