| 包装 | 价格(元) |
| 500μg | 电议 |
| 1mg | 电议 |
| 5mg | 电议 |
| 10mg | 电议 |
Cell lines | MSCs |
Preparation Method | The cells cultured for 24 hours with 50 uM of Myrtillin and stimulated or not with 1.25 g/mL of LPS. |
Reaction Conditions | 50 µM Myrtillin for 24 hours |
Applications | 50 µM Myrtillin increased the percentage of cells in the S/G2/M cycle phase. Mesenchymal stem cells produce soluble factors. |
Animal models | Rabbit |
Preparation Method | A rabbit model of atherosclerosis (AS) was established by 12 weeks of a high-fat diet (HFD). The rabbits were divided into five groups: control, AS, simvastatin (4 mg/kg), and two Myrtillin groups (10 and 20 mg/kg). After treatment with Myrtillin or simvastatin by oral gavage for 12 weeks, the lipid profiles were measured. |
Dosage form | 10 and 20 mg/kg Myrtillin for 12 weeks |
Applications | DP (20 mg/kg) decreased serum TG, TC, LDL-C, and HDL-C. Myrtillin (20 mg/kg) also reduced lipid levels in the liver and aorta. Myrtillin (20 mg/kg) down-regulated the mRNA levels of IL-6, VCAM-1, and NF-κB and up-regulated the mRNA levels of GSH-PX and SOD1. |
| 产品描述 | Myrtillin (Delphinidin 3-o-glucoside) is a kind of anthocyanin monomer, which is mainly distributed in various plants and can be analyzed qualitatively and quantitatively by high performance liquid chromatography (HPLC) Mass spectrometry (Mass) and nuclear magnetic resonance (NMR) Myrtillin at 50 uM does not affect cell viability, also showing that delphinidin in association with lipopolysaccharide was able to induce MSC proliferation. Additionally, delphinidin modulated the MSC immune response, showing increased levels of anti-inflammatory cytokines such as IL-10 and TGF-β as well as lower expression of NFκB[2]. Myrtillin showed potential for binding with and inhibiting immune checkpoints, PD-1 and PD-L1, which can activate immune response in the tumor microenvironment and induce cancer cell death[3]. Myrtillin (20 mg/kg) decreased serum TG, TC, LDL-C, and HDL-C. Myrtillin (20 mg/kg) also reduced lipid levels in the liver and aorta. Myrtillin (20 mg/kg) down-regulated the mRNA levels of IL-6, VCAM-1, and NF-κB and up-regulated the mRNA levels of GSH-PX and SOD1.DP alleviated the HFD-induced oxidative stress and inflammation in atherosclerosis rabbits[1]. References: |
m.cnreagent.com