Tephrosin (synthetic) 是一种天然类鱼素，具有强大的抗肿瘤活性。 Tephrosin（合成的）通过诱导受体的内化来诱导 EGFR 和 ErbB2 的降解。
| Cas No. | 76-80-2 |
| 别名 | 灰叶草素; Deguelinol I; Hydroxydeguelin |
| Canonical SMILES | CC(C=C1)(C)OC2=C1C(O3)=C(C=C2)C([C@@]([C@@]3([H])CO4)(O)C5=C4C=C(OC)C(OC)=C5)=O |
| 分子式 | C23H22O7 |
| 分子量 | 410.4 |
| 溶解度 | Chloroform: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tephrosin is a rotenoid first isolated from the leaves and seeds of T. purpurea and T. vogelii that exhibits antineoplastic and piscicidal activities. The toxic actions of this compound are attributed to its ability to inhibit the NADH:ubiquinone oxidoreductase with an IC50 value of 98nM. Tephrosin is also reported to induce ornithine decarboxylase activity with an IC50 value of 147 nM. Tephrosin has been shown to enhance the cytotoxic activity of 2-deoxy-D-glucose against various cancer human cancer cell lines, depleting intracellular ATP and inducing apoptosis. |
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