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HS-10296 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
HS-10296 hydrochloride图片
CAS NO:2134096-03-8
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Almonertinib (HS-10296) hydrochloride 是一种口服的、不可逆的第三代 EGFR 酪氨酸激酶抑制剂,对 EGFR 致敏和 T790M 耐药突变具有高选择性。 HS-10296 hydrochloride 对 T790M、T790M/L858R 和 T790M/Del19 具有很强的抑制活性(IC50 分别为 0.37、0.29 和 0.21 nM),而对野生型的抑制效果较差(3.39 nM)。 HS-10296 hydrochloride 用于非小细胞肺癌的研究。
Cas No.2134096-03-8
别名盐酸阿美替尼; HS-10296 hydrochloride
Canonical SMILESCOC(C=C(N(C)CCN(C)C)C(NC(C=C)=O)=C1)=C1NC2=NC(C3=CN(C4CC4)C5=C3C=CC=C5)=CC=N2.[H]Cl
分子式C30H36ClN7O2
分子量562.11
溶解度DMSO : 83.33 mg/mL (148.25 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

HS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR.

HS-10296 hydrochloride is an orally available inhibitor of the epidermal growth factor receptor (EGFR) mutant form T790M, with potential antineoplastic activity, which canbe used to treat NSCLC[1]. Additionaly, HS-10296 could also inhibit other EGFR sensitive mutations, including G719X, del19, L858R and L861Q[2].

[1]. Sullivan I, et al. Next-Generation EGFR Tyrosine Kinase Inhibitors for Treating EGFR-Mutant Lung Cancer beyond First Line. Front Med (Lausanne). 2017 Jan 18;3:76. [2]. Wu SG, et al. Management of acquired resistance to EGFR TKI-targeted therapy in advanced non-small cell lung cancer. Mol Cancer. 2018 Feb 19;17(1):38.