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K252b
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
K252b图片
CAS NO:99570-78-2
包装与价格:
包装价格(元)
500μg电议
1mg电议

产品介绍
K252b 是一种从放线菌 Nocardiopsis 中分离出来的吲哚并咔唑,是一种 PKC 抑制剂。
Cas No.99570-78-2
Canonical SMILESO[C@]1(C(O)=O)[C@](O[C@@]2([H])C1)(C)N3C4=CC=CC=C4C5=C3C(N2C6=CC=CC=C67)=C7C8=C5CNC8=O
分子式C26H19N3O5
分子量453.5
溶解度Methanol: 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

K252b is an indolocarbazole isolated from the actinomycete Nocardiopsis, first described as an inhibitor of protein kinase C. However, as this compound does not freely pass through the cell membrane, it is used to inhibit extracellular kinases (ectokinases) of cells in culture. K252b inhibits receptor-mediated degranulation from basophil-like RBL-2H3 cells (IC50 = 0.5 μg/ml) and human basophils. This extracellular inhibitor is also used in comparison studies with the closely related, cell-permeable inhibitor K252a, particularly in studies of neuronal differentiation.