Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 μM..
| Cas No. | 1020412-97-8 |
| Canonical SMILES | CC1=CC=C(C=C1)OC(N(CC(N[C@H](C2CCCCC2)C)=O)CC3=CC=C(C=C3)C4=CC(C(O)=O)=CN=C4)=O |
| 分子式 | C31H35N3O5 |
| 分子量 | 529.6 |
| 溶解度 | DMF: 14 mg/mL,DMSO: 20 mg/mL,DMSO:PBS (pH 7.2)(1:9): 0.1 mg/mL,Ethanol: 1 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Tie2 Inhibitor 7 blocks Tie2 kinase activity with a Ki value of 1.3 µM.. It has been shown to inhibit angiopoietin 1-induced Tie2 autophosphorylation and downstream signaling with an IC50 value of 0.3 µM. This compound can prevent endothelial cell tube formation and aberrant vessel growth in a rat model of Matrigel-induced choroidal neovascularization. |
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