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DX600(trifluoroacetate salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DX600(trifluoroacetate salt)图片
包装与价格：
包装价格(元)
500 µg电议
1mg电议

产品介绍
A peptide inhibitor of ACE2
Canonical SMILESNC(CNC(CNC(CNC([C@H](CCC(O)=O)NC([C@@H]1CCCN1C([C@@H](NC([C@@H]2CCCN2C([C@@H](NC([C@@]([C@@H](C)O)([H])NC([C@@H](NC([C@H](CCCCN)NC([C@@H](NC([C@@H](NC([C@@H]3CCCN3C([C@@H](NC([C@@H](NC([C@H](CCCNC(N)=N)NC([C@H](CC(C)C)NC([C@@H]4CCCN4C([C@H](CO)NC([C@@H](NC([C@@H](NC([C@H](CO)NC([C@@H](NC([C@@H](NC(CNC(C)=O)=O)CC(O)=O)=O)CC5=CC=C(O)C=C5)=O)=O)CC6=CN=CN6)=O)CS)=O)=O)=O)=O)=O)CC7=CC=C(O)C=C7)=O)CC8=CC=C(O)C=C8)=O)=O)CC9=CNC%10=C9C=CC=C%10)=O)CC%11=CNC%12=C%11C=CC=C%12)=O)=O)CS)=O)=O)CC%13=CC=C(O)C=C%13)=O)=O)CC(O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
分子式C141H187N35O40S2• XCF3COOH
分子量3076.4
溶解度DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:6): 0.13 mg/ml,Ethanol: slightly soluble
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DX600 is a potent and selective peptide inhibitor of angiotensin-converting enzyme 2 (ACE2; Kis = 2.8, 200, and 1,200 nM for recombinant, human, and murine ACE2, respectively).1,2ACE2 is an enzyme that is cardioprotective and renoprotective.3Inhibition of ACE2 with DX600 reducesin vitrovascular repair by CD34+stem/progenitor cells and exacerbates myocardial injury and dysfunctionin vivo.4,5

1.Huang, L., Sexton, D.J., Skogerson, K., et al.Novel peptide inhibitors of angiotensin-converting enzyme 2J. Biol. Chem.278(18)15532-15540(2003) 2.Joshi, S., Balasubramanian, N., Vasam, G., et al.Angiotensin converting enzyme versus angiotensin converting enzyme-2 selectivity of MLN-4760 and DX600 in human and murine bone marrow-derived cellsEur. J. Pharmacol.77425-33(2016) 3.Prada, J.A.H., Ferreira, A.J., Katovich, M.J., et al.Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agentsHypertension511312-1317(2008) 4.Singh, N., Joshi, S., Guo, L., et al.ACE2/Ang-(1-7)/Mas axis stimulates vascular repair-relevant functions of CD34+ cellsAm. J. Physiol. Heart. Circ. Physiol.309H1697-H1707(2015) 5.Song, B., Zhang, Z.-Z., Zhong, J.-C., et al.Loss of angiotensin-converting enzyme 2 exacerbates myocardial injury via activation of the CTGF-fractalkine signaling pathwayCirc. J.77(12)2997-3006(2013)