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YW1128
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YW1128图片
CAS NO:2131223-64-6
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
YW1128 (compound 3a) 是一种有效的 Wnt/β-Catenin 抑制剂。
Cas No.2131223-64-6
Canonical SMILESO=C(C1=C(C)N(C2=C(C)C=CC=C2)N=N1)NC3=CC=C(C=CC=C4)C4=N3
分子式C20H17N5O
分子量343.4
溶解度DMF: 30mg/mL,DMSO: 30mg/mL,Ethanol: 30mg/mL,PBS (pH 7.2): 2mg/mL
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

YW1128 is an inhibitor of Wnt/β-catenin signaling with an IC50 value of 4.1 nM in a reporter assay.1 It decreases protein levels of β-catenin in the presence of the GSK3β inhibitor lithium chloride and increases protein levels of Axin1 in HEK293 cells. YW1128 decreases lipid accumulation and the expression of gluconeogenic and lipogenic genes in Huh7 cells. It decreases the hepatic expression of Wnt target genes, improves glucose tolerance, and prevents body weight increases and hepatic lipid accumulation in mice fed a high-fat diet, but not mice fed normal chow, when administered at a dose of 40 mg/kg every other day for 11 weeks.

References
1. Obianom, O.N., Ai, Y., Li, Y., et al. Triazole-based inhibitors of the Wnt/β-catenin signaling pathway improve glucose and lipid metabolism in diet-induced obese mice. J. Med. Chem. 62(2), 727-741 (2019).