| CAS NO: | 137219-37-5 |
| 包装 | 价格(元) |
| 500 µg | 电议 |
| 1mg | 电议 |
| Cas No. | 137219-37-5 |
| 别名 | 普拉泰,Aplidine |
| Canonical SMILES | O=C1N2[C@](CCC2)([H])C(N([C@H](C(O[C@@H]([C@@H](C(N[C@]([C@H](CC(O[C@H](C([C@@H](C(N[C@H]1CC(C)C)=O)C)=O)C(C)C)=O)O)([H])[C@@H](C)CC)=O)NC([C@@H](CC(C)C)N(C)C([C@H]3N(C(C(C)=O)=O)CCC3)=O)=O)C)=O)CC4=CC=C(C=C4)OC)C)=O |
| 分子式 | C57H87N7O15 |
| 分子量 | 1110.3 |
| 溶解度 | DMSO: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Plitidepsin is a depsipeptide that was originally isolated fromAplidium albicansand has diverse biological activities.1,2,3It binds to the α subunit isoform eEF1A2 of eukaryotic elongation factor 1 (eEF1; Kd= 79 nM) and inhibits the proliferation of NCI H460 non-small cell lung cancer (NSCLC) and HGC-27 gastric cancer cells (IC50s = 0.2 and 0.9 nM, respectively).1Plitidepsin (0.01 nM) inhibits bone resorption by osteoclasts in a pit formation assay using bovine bone slices.2It reduces viral titers and lung inflammation in the K18-hACE2 mouse model of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection when administered at a dose of 0.3 mg/kg.3 1.Losada, A., MuÑoz-Alonso, M.J., GarcÍa, G., et al.Translation elongation factor eEF1A2 is a novel anticancer target for the marine natural product plitidepsinSci. Rep.635100(2016) 2.Delgado-Calle, J., Kurihara, N., Atkinson, E.G., et al.Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclastsOncotarget10(28)2709-2721(2019) 3.White, K.M., Rosales, R., Yildiz, S., et al.Plitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1AScience371(6532)926-931(2021) |
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