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Tuftsin(human)(trifluoroacetate salt)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Tuftsin(human)(trifluoroacetate salt)图片
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
A phagocytosis-stimulating peptide
Canonical SMILESC[C@@H](O)[C@H](N)C(N[C@@H](CCCCN)C(N1[C@H](C(N[C@H](C(O)=O)CCCNC(N)=N)=O)CCC1)=O)=O.OC(C(F)(F)F)=O
分子式C21H40N8O6·XCF3COOH
分子量500.6
溶解度DMF: 25 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml
储存条件-20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tuftsin is an endogenous peptide generated by proteolysis of leukokinin that stimulates phagocytosis.1It binds human polymorphonuclear leukocytes (PMN), human monocytes, and mouse macrophages with Kdvalues of 130, 125, and 53 nM, respectively.2Tuftsin (200 nM) increases phagocytosis of IgG-coated ovine red blood cells by 61% in isolated mouse peritoneal macrophages. It increases phagocytosis of the bacteriaS. aureusandL. monocytogenes, as well as the fungusS. oviformis, by isolated human, mouse, rabbit, dog, or guinea pig phagocytes when used at concentrations ranging from 0.01 to 0.15 µg/ml.3Tuftsin (0.1, 0.5, and 25 mg/kg) increases survival in a syngeneic mouse model of 2-methylcholanthrene-induced fibrosarcoma.4

1.Najjar, V.A., and Nishioka, K."Tuftsin": A natural phagocytosis stimulating peptideNature228(5272)672-673(1970) 2.Gottlieb, P., Stabinsky, Y., Hiller, T., et al.Tuftsin receptorsAnn. N. Y. Acad. Sci.41993-106(1983) 3.Martinez, J., and Winternitz, F.Bactericidal activity of tuftsinMol. Cell Biochem.41123-136(1981) 4.Catane, R., Schlanger, S., Weiss, L., et al.Toxicology and antitumor activity of tuftsinAnn. N. Y. Acad. Sci.419251-260(1983)