| CAS NO: | 80394-72-5 |
| 包装: | 1mg |
| 市场价: | 7031元 |
| Cas No. | 80394-72-5 |
| Canonical SMILES | O=C1C2=C(N=C(O1)N)N([C@@]3([H])[C@H](O)[C@H](O)[C@@H](CO)O3)C=N2 |
| 分子式 | C10H12N4O6 |
| 分子量 | 284.2 |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Oxanosine is an analog of guanosine that has been found inS. capreolusand has diverse biological activities, including antibacterial, antiviral, and anticancer properties.1,2It is active against a variety of bacteria, includingS. flexneri,P. mirabilis, andE. coli(MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively).1It also inhibits the growth of HeLa human cervical cancer cells (IC50= 32 µg/ml) and reduces tumor growth in a murine L1210 lymphocytic leukemia model.2 1.Saito, Y., Nakamura, M., Ohno, T., et al.Syntheses of oxanosine and carbocyclic oxanosine derivatives as anti-HIV agentsJ. Antibiot. (Tokyo)53(3)309-313(2000) 2.Shimada, N., Yagisawa, N., Naganawa, H., et al.Oxanosine, a novel nucleoside from actinomycetesJ. Antibiot. (Tokyo)34(9)1216-1218(1981) |
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