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Hydrocortisone-d4
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Hydrocortisone-d4图片
CAS NO:73565-87-4
包装与价格：
包装价格(元)
500 μg电议
1mg电议
5mg电议

产品介绍
An internal standard for the quantification of hydrocortisone
Cas No.73565-87-4
别名氘代氢化可的松,Cortisol-d4
Canonical SMILESO=C1CC[C@@]2(C)C(CC[C@]3([H])[C@]2([2H])[C@](O)([2H])C([2H])([2H])[C@@]4(C)[C@@]3([H])CC[C@]4(O)C(CO)=O)=C1
分子式C21H26D4O5
分子量366.5
溶解度DMF: 30 mg/ml,DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml,DMSO: 20 mg/ml,Ethanol: 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Hydrocortisone-d4is intended for use as an internal standard for the quantification of hydrocortisone/cortisol by GC- or LC-MS. Cortisol, known as hydrocortisone when used as a therapeutic, is a glucocorticoid produced by the adrenal cortex in response to adrenocorticotropic hormone (ACTH).1,2It is an agonist at the mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR), with an approximately 6- to 10-fold greater affinity for MR. Cortisol production is increased during periods of stress, and it is a major effector molecule in the hypothalamic-pituitary-adrenal axis (HPA) stress response.2Cortisol levels increase with age and are often elevated in major depressive disorder, certain forms of hypertension, and Parkinson's disease.3,4,5

1.Krieger, D.T.Rhythms of ACTH and corticosteroid secretion in health and disease, and their experimental modificationJ. Steroid Biochem.6(5)785-791(1975) 2.Dunlop, B.W., and Wong, A.The hypothalamic-pituitary-adrenal axis in PTSD: Pathophysiology and treatment interventionsProg. Neuropsychopharmacol. Biol. Psychiatry89361-379(2019) 3.Quinkler, M., and Stewart, P.M.Hypertension and the cortisol-cortisone shuttleJ. Clin. Endocrinol. Metab.88(6)2384-2392(2003) 4.Varghese, F.P., and Brown, E.S.The hypothalamic-pituitary-adrenal axis in major depressive disorder: A brief primer for primary care physiciansPrim. Care Companion J. Clin. Psychiatry3(4)151-155(2001) 5.Soares, N.M., Pereira, G.M., Altmann, V., et al.Cortisol levels, motor, cognitive and behavioral symptoms in Parkinson's disease: A systematic reviewJ. Neural Transm. (Vienna)(2018)