您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > Cyprodinil
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Cyprodinil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cyprodinil图片
CAS NO:121552-61-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Cyprodinil 是一种苯胺嘧啶类广谱杀菌剂,可抑制植物病原真菌中蛋氨酸的生物合成。
Cas No.121552-61-2
别名嘧菌环胺
Canonical SMILESCC1=CC(C2CC2)=NC(NC3=CC=CC=C3)=N1
分子式C14H15N3
分子量225.3
溶解度Chloroform: Slightly Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Cyprodinil is an anilinopyrimidine broad-spectrum fungicide that inhibits the biosynthesis of methionine in phytopathogenic fungi.1It inhibits mycelial cell growth ofB. cinerea, P. herpotrichoides, andH. oryzaeon amino acid-free media (IC50s = 0.44, 4.8, and 0.03 µM, respectively), an effect that is reversed by addition of methionine or homocysteine. In an MDA-kb2 assay, cyprodinil acts as an androgen receptor (AR) agonist (EC20= 1.91 µM) in the absence of the AR agonist DHT and inhibits the androgenic effect of DHT (IC20= 15.1 µM).2It is cytotoxic in a yeast antiandrogen screen (YAS; EC20= 27.8 µM) but not in an MDA-kb2 assay (EC20= >50 µM). Cyprodinil increases proliferation of estrogen receptor-expressing BG-1 ovarian cancer cells when used at low micromolar concentrations in combination with 17β-estradiol.3It also increases tumor mass in a BG-1 ovariectomized mouse xenograft model after 70 days when administered at a dose of 3 mg/kg every three days. Formulations containing cyprodinil have been used in the control of fungi in agriculture.

1.Masner, P., Muster, P., and Schmid, J.Possible methionine biosynthesis inhibition by pyrimidinamine fungicidesPestic. Sci.42(3)163-166(1994) 2.Orton, F., Rosivatz, E., Scholze, M., et al.Widely used pesticides with previously unknown endocrine activity revealed as in vitro antiandrogensEnviron. Health Perspect.119(6)794-800(2011) 3.Go, R.-E., Kim, C.-W., and Choi, K.-C.Effect of fenhexamid and cyprodinil on the expression of cell cycle- and metastasis-related genes via an estrogen receptor-dependent pathway in cellular and xenografted ovarian cancer modelsToxicol. Appl. Pharmacol.289(1)48-57(2015)