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LY2444296
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
LY2444296图片
CAS NO:1346133-11-6
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
LY2444296 是一种有口服生物活性、高亲和力、选择性的短效的 KOPR 拮抗剂，其 Ki 值为 ~1 nM。LY2444296 具有抗焦虑样的作用。
Cas No.1346133-11-6
别名FP3FBZ
Canonical SMILESO=C(N)C1=CC=C(OC2=CC=C(CN3[C@H](C4=CC=CC(F)=C4)CCC3)C=C2)C(F)=C1
分子式C24H22F2N2O2
分子量408.44
溶解度Ethanol: 27.5 mg/mL (67.33 mM); Methanol: 5 mg/mL (12.24 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

LY2444296 is an orally bioavailable, high-affinity and selective short-acting kappa opioid receptor (KOPR) antagonist, with a Ki value of ∼1 nM. LY2444296 exhibits anti-anxiety like effects[1][2].

[1]. Huang P, et al. Two short-acting kappa opioid receptor antagonists (zyklophin and LY2444296) exhibited different behavioral effects from the long-acting antagonist norbinaltorphimine in mouse anxiety tests. Neurosci Lett. 2016 Feb 26;615:15-20. [2]. Valenza M, et al. "Effects of the novel relatively short-acting kappa opioid receptor antagonist LY2444296 in behaviors observed after chronic extended-access cocaine self-administration in rats". Psychopharmacology (Berl). 2017 Aug;234(15):2219-2231.